Gfral^em1Oyad
Endonuclease-mediated Allele Detail

Summary

• Symbol: Gfral^em1Oyad
• Name: GDNF family receptor alpha like; endonuclease-mediated mutation 1, Seiichi Oyadomari
• MGI ID: MGI:7384321
• Gene: Gfral Location: Chr9:76071389-76120939 bp, - strand Genetic Position: Chr9, 42.48 cM
• Alliance: Gfral^em1Oyad page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• CRISPR-targeting of exon 5 generated a null allele. (J:330706)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Gfral Mutation: 33 strains or lines available

References

• Original: J:330706 Miyake M, et al., Integrated stress response regulates GDF15 secretion from adipocytes, preferentially suppresses appetite for a high-fat diet and improves obesity. iScience. 2021 Dec 17;24(12):103448
• All: 1 reference(s)