Calcb^tm1Eme
Targeted Allele Detail

Summary

• Symbol: Calcb^tm1Eme
• Name: calcitonin-related polypeptide, beta; targeted mutation 1, Ronald Emeson
• MGI ID: MGI:7382803
• Synonyms: betaCGRP-null
• Gene: Calcb Location: Chr7:114317878-114322600 bp, + strand Genetic Position: Chr7, 60.19 cM, cytoband F3
• Alliance: Calcb^tm1Eme page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:330640
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 3 kb region containing part of exon 3 through exon 4 was deleted and replaced with a DNA fragment encoding EGFP. The EGFP sequence was inserted after the codon for amino acid residue 37, resulting in the expression of a fusion protein containing the endogenous gene signal peptide sequence and EGFP. (J:330640)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Calcb Mutation: 15 strains or lines available

References

• Original: J:330640 Thompson BJ, et al., Protective roles of alpha-calcitonin and beta-calcitonin gene-related peptide in spontaneous and experimentally induced colitis. Dig Dis Sci. 2008 Jan;53(1):229-41
• All: 4 reference(s)