Bckdk^em1Zara
Endonuclease-mediated Allele Detail

Summary

• Symbol: Bckdk^em1Zara
• Name: branched chain ketoacid dehydrogenase kinase; endonuclease-mediated mutation 1, Zoltan Arany
• MGI ID: MGI:7382739
• Synonyms: Bckdk^fl
• Gene: Bckdk Location: Chr7:127503245-127508836 bp, + strand Genetic Position: Chr7, 69.82 cM
• Alliance: Bckdk^em1Zara page

Mutation origin

• Strain of Origin: (C57BL/6 x SJL)F1

Mutation description

• Allele Type: Endonuclease-mediated (Conditional ready)
• Mutation: Insertion
• Mutation details: Using CRISPR/Cas9 technology, loxP sites were inserted in introns between exons 4 and 5 and between exons 8 and 9. (J:330611)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Bckdk Mutation: 45 strains or lines available

References

• Original: J:330611 Murashige D, et al., Extra-cardiac BCAA catabolism lowers blood pressure and protects from heart failure. Cell Metab. 2022 Nov 1;34(11):1749-1764.e7
• All: 1 reference(s)