Nsd1^tm1.1Luch
Targeted Allele Detail

Summary

• Symbol: Nsd1^tm1.1Luch
• Name: nuclear receptor-binding SET-domain protein 1; targeted mutation 1.1, Chao Lu
• MGI ID: MGI:7378760
• Synonyms: Nsd1^f
• Gene: Nsd1 Location: Chr13:55357595-55466138 bp, + strand Genetic Position: Chr13, 29.8 cM
• Alliance: Nsd1^tm1.1Luch page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:330345
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: (129/SvEv x C57BL/6)

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: LoxP sites were inserted surrounding exon 3 via homologous recombination. The neo selection cassette was removed. (J:330345)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nsd1 Mutation: 278 strains or lines available

Notes

ES cells = HF4

References

• Original: J:330345 Li Y, et al., Histone methylation antagonism drives tumor immune evasion in squamous cell carcinomas. Mol Cell. 2022 Oct 20;82(20):3901-3918.e7
• All: 1 reference(s)