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Wlstm1.2Lan
Targeted Allele Detail
Summary
Symbol: Wlstm1.2Lan
Name: wntless WNT ligand secretion mediator; targeted mutation 1.2, Richard A Lang
MGI ID: MGI:7378702
Gene: Wls  Location: Chr3:159545309-159644300 bp, + strand  Genetic Position: Chr3, 82.65 cM
Alliance: Wlstm1.2Lan page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:260471
Parent Cell Line:  Duffy (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA targeting vector was designed to insert a loxP site upstream of the coding sequence in exon 1, followed by an frt-flanked neomycin resistance (neo) cassette and a second loxP site upstream of exon 2 of the wntless homolog (Drosophila) (Wls) gene. Flp mediated recombination removed the neo cassette leaving the coding sequence of exon 1 floxed. Cre-mediated recombination removed exon 1. (J:260471)
Expression
In Mice Carrying this Mutation: 2 RNA-Seq or microarray experiment(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Wls Mutation:  36 strains or lines available
References
Original:  J:260471 Gerhardt B, et al., Notum attenuates Wnt/beta-catenin signaling to promote tracheal cartilage patterning. Dev Biol. 2018 Apr 1;436(1):14-27
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/25/2025
MGI 6.24
The Jackson Laboratory