Cd40^tm1.1Wgnr
Targeted Allele Detail

Summary

• Symbol: Cd40^tm1.1Wgnr
• Name: CD40 antigen; targeted mutation 1.1, David Wagner
• MGI ID: MGI:7367364
• Synonyms: CD40^fl
• Gene: Cd40 Location: Chr2:164897535-164913574 bp, + strand Genetic Position: Chr2, 85.38 cM
• Alliance: Cd40^tm1.1Wgnr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:330273
• Parent Cell Line: EC7.1 (ES Cell)
• Strain of Origin: (C57BL/6J x 129X1/SvJ)F1

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: The targeting vector is designed to insert loxP sites flanking exon 1, and a downstream FRT-flanked neomycin resistance cassette is also inserted. Flp recombinase-mediated recombination removed the neo cassette. (J:330273)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Cd40 Mutation: 42 strains or lines available

References

• Original: J:330273 Lu Y, et al., CD40 Drives Central Nervous System Autoimmune Disease by Inducing Complementary Effector Programs via B Cells and Dendritic Cells. J Immunol. 2022 Oct 12
• All: 1 reference(s)