Nppb^em4Vmc
Endonuclease-mediated Allele Detail

Summary

• Symbol: Nppb^em4Vmc
• Name: natriuretic peptide type B; endonuclease-mediated mutation 4, Vincent M Christoffels
• MGI ID: MGI:7366945
• Synonyms: Nppb³⁹⁸
• Gene: Nppb Location: Chr4:148070264-148071662 bp, + strand Genetic Position: Chr4, 78.57 cM
• Alliance: Nppb^em4Vmc page

Mutation origin

• Strain of Origin: Not Applicable

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: The biologically active domain coded for in exon 2 was targeted with sgRNAs using CRISPRCas9 technology, resulting in a 398 bp deletion encompassing the 3' end of exon 1, entire intron 1 and most of exon 2. (J:309962)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nppb Mutation: 14 strains or lines available

References

• Original: J:309962 Man JCK, et al., Genetic Dissection of a Super Enhancer Controlling the Nppa-Nppb Cluster in the Heart. Circ Res. 2021 Jan 8;128(1):115-129
• All: 1 reference(s)