Dsg3^{tm1.1(DSG3)Geno}
Targeted Allele Detail

Summary

• Symbol: Dsg3^{tm1.1(DSG3)Geno}
• Name: desmoglein 3; targeted mutation 1.1, Genoway
• MGI ID: MGI:7366904
• Gene: Dsg3 Location: Chr18:20643331-20674367 bp, + strand Genetic Position: Chr18, 11.39 cM
• Alliance: Dsg3^{tm1.1(DSG3)Geno} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:329987
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Targeted (Conditional ready, Humanized sequence, Inserted expressed sequence)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 2-5 were replaced by a loxP-flanked in-frame fusion of a chimeric human DSG3 extracellular domain and a murine Dsg3 transmembrane and intracellular domain cDNA. An FRT-flanked selection cassette was removed via flp-mediated recombination. (J:329987)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dsg3 Mutation: 72 strains or lines available

References

• Original: J:329987 Hudemann C, et al., IgG against the Membrane-Proximal Portion of the Desmoglein 3 Ectodomain Induces Loss of Keratinocyte Adhesion, a Hallmark in Pemphigus Vulgaris. J Invest Dermatol. 2022 Sep 9
• All: 1 reference(s)