Tg(SFTPC-SFTPA2*)T10Jflo
Transgene Detail

Summary

• Symbol: Tg(SFTPC-SFTPA2*)T10Jflo
• Name: transgene insertion T10, Joanna Floros
• MGI ID: MGI:7365216
• Synonyms: hTG SP-A2(1A⁰)
• Transgene: Tg(SFTPC-SFTPA2*)T10Jflo Location: unknown
• Alliance: Tg(SFTPC-SFTPA2*)T10Jflo page

Transgene origin

• Strain of Origin: C57BL/6

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(SFTPC-SFTPA2*)T10Jflo expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  SFTPA2 (729238)

  Sftpa1

  (MGI:109518)

  variant 1A0 coding sequence

• Mutation details: The transgenic construct contains the 3.7 kb human SFTPC (surfactant associated protein C) promoter, the 1.3 kb human SFTPA2 (surfactant associated protein A2) variant 1A0 coding sequence containing the 5’ and 3’ UTR and the entire coding region followed by an SV40 polyA signal. Founder line T10 was established. (J:161087)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:161087 Wang G, et al., Humanized SFTPA1 and SFTPA2 transgenic mice reveal functional divergence of SP-A1 and SP-A2: formation of tubular myelin in vivo requires both gene products. J Biol Chem. 2010 Apr 16;285(16):11998-2010
• All: 2 reference(s)