Tg(SFTPC-SFTPA1*)T1Jflo
Transgene Detail

Summary

• Symbol: Tg(SFTPC-SFTPA1*)T1Jflo
• Name: transgene insertion T1, Joanna Floros
• MGI ID: MGI:7365197
• Synonyms: hTG SP-A1(6A²)
• Transgene: Tg(SFTPC-SFTPA1*)T1Jflo Location: unknown
• Alliance: Tg(SFTPC-SFTPA1*)T1Jflo page

Transgene origin

• Strain of Origin: C57BL/6

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(SFTPC-SFTPA1*)T1Jflo expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  SFTPA1 (653509)

  Sftpa1

  (MGI:109518)

  variant 6A2 coding sequence

• Mutation details: The transgenic construct contains the 3.7 kb human SFTPC (surfactant associated protein C) promoter, the 1.3 kb human SFTPA1 (surfactant associated protein A1) variant 6A2 coding sequence containing the 5'; and 3' UTR and the entire coding region followed by an SV40 polyA signal. Founder line T1 was established. (J:161087)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:161087 Wang G, et al., Humanized SFTPA1 and SFTPA2 transgenic mice reveal functional divergence of SP-A1 and SP-A2: formation of tubular myelin in vivo requires both gene products. J Biol Chem. 2010 Apr 16;285(16):11998-2010
• All: 1 reference(s)