Tg(SFTPC-SFTPA1*)T2Jflo
Transgene Detail
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Symbol: |
Tg(SFTPC-SFTPA1*)T2Jflo |
Name: |
transgene insertion T2, Joanna Floros |
MGI ID: |
MGI:7365194 |
Synonyms: |
hTG SP-A1(6A4) |
Transgene: |
Tg(SFTPC-SFTPA1*)T2Jflo Location: unknown Genetic Position: ChrUN, Syntenic
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Alliance: |
Tg(SFTPC-SFTPA1*)T2Jflo page
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Transgene Type: |
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Transgenic (Humanized sequence, Inserted expressed sequence) |
Mutation: |
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Insertion
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Tg(SFTPC-SFTPA1*)T2Jflo expresses
1 gene
Transgene expresses:
Organism |
Expressed Gene |
Homolog in Mouse |
Note |
human |
SFTPA1 (653509) |
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variant 6A4 coding sequence |
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Mutation details: The transgenic construct contains the 3.7 kb human SFTPC (surfactant associated protein C) promoter, the 1.3 kb human SFTPA1 (surfactant associated protein A1) variant 6A4 coding sequence containing the 5' and 3'; UTR and the entire coding region followed by an SV40 polyA signal. Founder line T2 exhibit higher protein expression than the other founder lines.
(J:161087)
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 1 strain available
Cell Lines: 0 lines available
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Original: |
J:161087 Wang G, et al., Humanized SFTPA1 and SFTPA2 transgenic mice reveal functional divergence of SP-A1 and SP-A2: formation of tubular myelin in vivo requires both gene products. J Biol Chem. 2010 Apr 16;285(16):11998-2010 |
All: |
1 reference(s) |
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