Park7^tm1.1Xko
Targeted Allele Detail

Summary

• Symbol: Park7^tm1.1Xko
• Name: Parkinson disease (autosomal recessive, early onset) 7; targeted mutation 1.1, Xiaoni Kong
• MGI ID: MGI:7356317
• Synonyms: Dj-1^f
• Gene: Park7 Location: Chr4:150981590-150994378 bp, - strand Genetic Position: Chr4, 81.52 cM, cytoband E1
• Alliance: Park7^tm1.1Xko page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:329969
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 2 and an FRT-flanked PGK-Neo cassette and second loxP site were inserted downstream of exon 3. The selection cassette was removed via flp-mediated recombination, leaving exons 2 and 3 floxed. (J:329969)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Park7 Mutation: 56 strains or lines available

References

• Original: J:329969 Xu M, et al., DJ-1 Deficiency in Hepatocytes Improves Liver Ischemia-Reperfusion Injury by Enhancing Mitophagy. Cell Mol Gastroenterol Hepatol. 2021;12(2):567-584
• All: 1 reference(s)