Tgfbi^tm1.1Sjc
Targeted Allele Detail

Summary

• Symbol: Tgfbi^tm1.1Sjc
• Name: transforming growth factor, beta induced; targeted mutation 1.1, Simon J Conway
• MGI ID: MGI:7344036
• Synonyms: Tgfbi^lacZ
• Gene: Tgfbi Location: Chr13:56757399-56787172 bp, + strand Genetic Position: Chr13, 30.09 cM, cytoband B-C1
• Alliance: Tgfbi^tm1.1Sjc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:231522
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: An IRES-lacZ-neo-loxP cassette replaced the translation start site and all of the first exon. The lacZ reporter is expressed under the control of the endogenous gene promoter. The IRES-lacZ-neo-loxP cassette was removed via Cre-mediated recombination in the germline. (J:231522)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tgfbi Mutation: 39 strains or lines available

References

• Original: J:231522 Ahlfeld SK, et al., Initial Suppression of Transforming Growth Factor-beta Signaling and Loss of TGFBI Causes Early Alveolar Structural Defects Resulting in Bronchopulmonary Dysplasia. Am J Pathol. 2016 Apr;186(4):777-93
• All: 2 reference(s)