Tg(Rr279-GH1)11Mrub
Transgene Detail
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Symbol: |
Tg(Rr279-GH1)11Mrub |
Name: |
transgene insertion 11, Marcelo Rubinstein |
MGI ID: |
MGI:7341856 |
Transgene: |
Tg(Rr279-GH1)11Mrub Location: unknown
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Alliance: |
Tg(Rr279-GH1)11Mrub page
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Strain of Origin: |
Not Applicable
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Transgene Type: |
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Transgenic (Inserted expressed sequence) |
Mutation: |
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Insertion
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Tg(Rr279-GH1)11Mrub expresses
1 gene
Transgene expresses:
Organism |
Expressed Gene |
Homolog in Mouse |
Note |
human |
CSH1 (1442) |
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Mutation details: The transgene contains the following elements: a neuron-specific enhancers-containing region 9-13 kb upstream of the Pomc gene transcription start site with enhancer Rr280 deleted but Rr279 still present, the Herpes simplex virus TK gene minimal promoter and the human growth hormone gene gene. The transgene is expressed in hypothalamic arcuate neurons but not in pituitary melanotrophs and corticotrophs during embryonic development.
(J:97636)
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Original: |
J:97636 de Souza FS, et al., Identification of neuronal enhancers of the proopiomelanocortin gene by transgenic mouse analysis and phylogenetic footprinting. Mol Cell Biol. 2005 Apr;25(8):3076-86 |
All: |
1 reference(s) |
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