Plk4em5Ahol
Endonuclease-mediated Allele Detail
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Symbol: |
Plk4em5Ahol |
Name: |
polo like kinase 4; endonuclease-mediated mutation 5, Andrew Holland |
MGI ID: |
MGI:7341837 |
Synonyms: |
Plk4cWT |
Gene: |
Plk4 Location: Chr3:40754463-40771318 bp, + strand Genetic Position: Chr3, 19.54 cM
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Alliance: |
Plk4em5Ahol page
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Strain of Origin: |
(C57BL/6 x SJL/J)F1
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Allele Type: |
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Endonuclease-mediated (Conditional ready) |
Mutation: |
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Insertion
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Mutation details: CRISPR/cas9 genome editing uses guide RNAs, targeting DNA sequence 5';-aagctaggactttaatactc-3', to insert a loxP flanked STOP cassette into intron 4. Plk4-201 was used as reference for the exon number and the guide sequences.
(J:329155)
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Plk4 Mutation: |
36 strains or lines available
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Original: |
J:329155 LoMastro GM, et al., PLK4 drives centriole amplification and apical surface area expansion in multiciliated cells. Elife. 2022 Aug 15;11:e80643 |
All: |
1 reference(s) |
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