Gjd2^tm2.1Paul
Targeted Allele Detail

Summary

• Symbol: Gjd2^tm2.1Paul
• Name: gap junction protein, delta 2; targeted mutation 2.1, David L Paul
• MGI ID: MGI:7341594
• Synonyms: Cx36fl
• Gene: Gjd2 Location: Chr2:113840082-113844100 bp, - strand Genetic Position: Chr2, 57.54 cM, cytoband F3
• Alliance: Gjd2^tm2.1Paul page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:269358
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxp flanked TK/neomycin selection cassette was inserted upstream of exon 2 and a third loxP site was inserted downstream of the exon 2 coding region within the non-coding region of the exon. The selection cassette was removed via cre-recombinase transfection in ES cells leaving exon 2 floxed. (J:269358)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gjd2 Mutation: 25 strains or lines available

References

• Original: J:269358 Yao X, et al., Gap Junctions Contribute to Differential Light Adaptation across Direction-Selective Retinal Ganglion Cells. Neuron. 2018 Oct 10;100(1):216-228.e6
• All: 7 reference(s)