Ptgdr2^em1Yyu
Endonuclease-mediated Allele Detail

Summary

• Symbol: Ptgdr2^em1Yyu
• Name: prostaglandin D2 receptor 2; endonuclease-mediated mutation 1, Ying Yu
• MGI ID: MGI:7341545
• Synonyms: CRTH2^flox
• Gene: Ptgdr2 Location: Chr19:10914524-10919875 bp, + strand Genetic Position: Chr19, 7.4 cM
• Alliance: Ptgdr2^em1Yyu page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Conditional ready)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 3 and a second loxP site was inserted within exon 3 such that the coding region is floxed, via CRISPR/cas9 technology. (J:328890)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ptgdr2 Mutation: 15 strains or lines available

References

• Original: J:328890 Zuo S, et al., ER-anchored CRTH2 antagonizes collagen biosynthesis and organ fibrosis via binding LARP6. EMBO J. 2021 Jul 5;:e107403
• All: 1 reference(s)