Kif11^tm1.2Nat
Targeted Allele Detail

Summary

• Symbol: Kif11^tm1.2Nat
• Name: kinesin family member 11; targeted mutation 1.2, Jeremy Nathans
• MGI ID: MGI:7341372
• Gene: Kif11 Location: Chr19:37364851-37410307 bp, + strand Genetic Position: Chr19, 32.27 cM
• Alliance: Kif11^tm1.2Nat page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:328905
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: LoxP sites were introduced to introns 4 and 6. An FRT-flanked neomycin cassette was inserted adjacent to the 5' loxP site. Exons 5 and 6 were removed via cre-mediated recombination. The neomycin cassette is present. Deletion of exons 5 and 6 leads to a 311 bp deletion resulting in a frameshift starting at codon 129 of the 1052 codon open reading frame. (J:328905)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Kif11 Mutation: 61 strains or lines available

References

• Original: J:328905 Wang Y, et al., A mouse model for kinesin family member 11 (Kif11)-associated familial exudative vitreoretinopathy. Hum Mol Genet. 2020 May 8;29(7):1121-1131
• All: 1 reference(s)