Prmt7^{tm1c(EUCOMM)Wtsi}
Targeted Allele Detail

Summary

• Symbol: Prmt7^{tm1c(EUCOMM)Wtsi}
• Name: protein arginine N-methyltransferase 7; targeted mutation 1c, Wellcome Trust Sanger Institute
• MGI ID: MGI:7338922
• Synonyms: Prmt7^flox
• Gene: Prmt7 Location: Chr8:106937686-106978326 bp, + strand Genetic Position: Chr8, 53.11 cM
• Alliance: Prmt7^{tm1c(EUCOMM)Wtsi} page
• IMPC: Prmt7 gene page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:327329
• Parent Cell Line: JM8.N4 (ES Cell)
• Strain of Origin: C57BL/6N
• Project Collection: EUCOMM

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: The L1L2_gt2 cassette was inserted at position 106943447 of Chromosome 8 upstream of the critical exon(s) (Build GRCm39). The cassette is composed of an FRT flanked lacZ/neomycin sequence followed by a loxP site. An additional loxP site is inserted downstream of the targeted exon(s) at position 106944136. The critical exon(s) is/are thus flanked by loxP sites. A "conditional ready" (floxed) allele was created by flp recombinase expression in mice carrying this allele to remove the lacZ sequence and neo selection cassette, leaving loxP sites flanking the critical exon(s). Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml (J:327329)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Prmt7 Mutation: 39 strains or lines available

References

• Original: J:327329 Gunes Gunsel G, et al., The arginine methyltransferase PRMT7 promotes extravasation of monocytes resulting in tissue injury in COPD. Nat Commun. 2022 Mar 14;13(1):1303
• All: 3 reference(s)