Masp1^em1Tefu
Endonuclease-mediated Allele Detail

Summary

• Symbol: Masp1^em1Tefu
• Name: MBL associated serine protease 1; endonuclease-mediated mutation 1, Teizo Fujita
• MGI ID: MGI:7336299
• Synonyms: Masp1^-
• Gene: Masp1 Location: Chr16:23268167-23339565 bp, - strand Genetic Position: Chr16, 14.23 cM, cytoband B2-B3
• Alliance: Masp1^em1Tefu page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Endonuclease-mediated (Modified isoform(s))
• Mutation: Intragenic deletion
• Mutation details: CRISPR-targeting deleted exons 1318 of the Masp1 gene to monospecifically deficient in MASP-1 protein isoform. (J:279043)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Masp1 Mutation: 46 strains or lines available

References

• Original: J:279043 Hayashi M, et al., Cutting Edge: Role of MASP-3 in the Physiological Activation of Factor D of the Alternative Complement Pathway. J Immunol. 2019 Sep 15;203(6):1411-1416
• All: 1 reference(s)