Gt(ROSA)26Sor^{tm1(Fgf8)Will}
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{tm1(Fgf8)Will}
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Trevor Williams
• MGI ID: MGI:7335086
• Synonyms: R26^{LSL Fgf8b}
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{tm1(Fgf8)Will} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:276631
• Parent Cell Line: W9.5/W95 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, Inserted expressed sequence, Reporter)
• Mutation: Insertion
• Gt(ROSA)26Sor^{tm1(Fgf8)Will} expresses 1 gene
  Knock-in expresses:
  

  Organism	Expressed Gene	Note
  mouse	Fgf8 (MGI:99604)

• Mutation details: A construct containing a splice acceptor, floxed stop cassette, mouse Fgf8 cDNA, and IRES-GFP was inserted downstream of the endogenous promoter. (J:276631)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 1084 strains or lines available

References

• Original: J:276631 Schmidt L, et al., Increased FGF8 signaling promotes chondrogenic rather than osteogenic development in the embryonic skull. Dis Model Mech. 2018 Jun 15;11(6):dmm031526
• All: 1 reference(s)