Tg(DMD*)Idel52Lumc
Transgene Detail

Summary

• Symbol: Tg(DMD*)Idel52Lumc
• Name: transgene insertion Idel52, Leiden University Medical Centre
• MGI ID: MGI:7333121
• Synonyms: hDMDdel52
• Transgene: Tg(DMD*)Idel52Lumc Location: unknown Genetic Position: Chr5, Syntenic
• Alliance: Tg(DMD*)Idel52Lumc page

Mutation origin

• Strain of Origin: STOCK Tg(DMD)72Thoen Dmd^mdx/Lumc

Mutation description

• Allele Type: Endonuclease-mediated (No functional change)
• Mutation: Insertion
• Tg(DMD*)Idel52Lumc expresses 1 gene
  Knock-in expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  DMD (1756)

  Dmd	(MGI:94909)

• Mutation details: TALEN-targeting of exon 52 produced a partial deletion of the 5' end of exon 52 and a 2.3 kb inversion including intron 51 and the last 93 bp of exon 52 in both copies of the transgene. Loss of exon 52 results in the loss of DMD protein expression. (J:299478)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:299478 Yavas A, et al., Detailed genetic and functional analysis of the hDMDdel52/mdx mouse model. PLoS One. 2020;15(12):e0244215
• All: 2 reference(s)