Mirc35^tm1Dgk
Targeted Allele Detail

Summary

• Symbol: Mirc35^tm1Dgk
• Name: microRNA cluster 35, including Mir182 through Mir183; targeted mutation 1, David Kirsch
• MGI ID: MGI:7331611
• Synonyms: miR-183C
• Gene: Mirc35 Location: Chr6:30165917-30169736 bp Genetic Position: Chr6, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:327360
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: The targeting vector is designed to insert a loxP site upstream of the Mir182 coding region and an FRT-flanked neomycin resistance (neo) cassette downstream of the Mir183 coding region on chromosome 6. The region includes the Mirc35 cluster: Mir182, Mir96, and Mir183. (J:327360)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Mirc35 Mutation: 4 strains or lines available

References

• Original: J:327360 Wang Z, et al., Deletion of microRNA-183-96-182 Cluster in Lymphocytes Suppresses Anti-DsDNA Autoantibody Production and IgG Deposition in the Kidneys in C57BL/6-Fas(lpr/lpr) Mice. Front Genet. 2022;13:840060
• All: 1 reference(s)