Gt(ROSA)26Sor^{em1(CAG-Nsd3*T1242A)Pkma}
Endonuclease-mediated Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{em1(CAG-Nsd3*T1242A)Pkma}
• Name: gene trap ROSA 26, Philippe Soriano; endonuclease-mediated mutation 1, Pawel K Mazur
• MGI ID: MGI:7331558
• Synonyms: LSL-Nsd3^T1242A
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{em1(CAG-Nsd3*T1242A)Pkma} page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Conditional ready, Inserted expressed sequence)
• Mutation: Insertion
• Gt(ROSA)26Sor^{em1(CAG-Nsd3*T1242A)Pkma} expresses 1 gene
  Knock-in expresses:
  

  Organism	Expressed Gene	Note
  mouse	Nsd3 (MGI:2142581)

• Mutation details: A CAG-loxP-Stop-loxP-V5-mouse Nsd3 cDNA containing a threonine to alanine substitution at amino acid 1242 (p.T1242A)-polyA cassette was inserted into intron 1. (J:302098)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 1060 strains or lines available

References

• Original: J:302098 Yuan G, et al., Elevated NSD3 histone methylation activity drives squamous cell lung cancer. Nature. 2021 Feb;590(7846):504-508
• All: 1 reference(s)