Cdkn1b^{tm1.1 Hjak}
Targeted Allele Detail

Summary

• Symbol: Cdkn1b^{tm1.1 Hjak}
• Name: cyclin dependent kinase inhibitor 1B; targeted mutation 1.1, Heidelinde Jakel
• MGI ID: MGI:7330388
• Synonyms: p27-Y88F
• Gene: Cdkn1b Location: Chr6:134897364-134902476 bp, + strand Genetic Position: Chr6, 65.77 cM
• Alliance: Cdkn1b^{tm1.1 Hjak} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:326295
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Not Specified)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: The gene was modified by insertion of a loxP-flanked neomycin resistance cassette in intron 2 and an A-to-T mutation in exon 1, changing tyrosine codon 88 (TAC) to phenylalanine (TTC) in the CDK-binding domain coding region (c.263A>T, p.Y88F). The Neomycin cassette was excised by breeding with Sox2-Cre mice. (J:326295)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cdkn1b Mutation: 26 strains or lines available

References

• Original: J:326295 Jakel H, et al., Inability to phosphorylate Y88 of p27(Kip1) enforces reduced p27 protein levels and accelerates leukemia progression. Leukemia. 2022 Jul;36(7):1916-1925
• All: 1 reference(s)