Ddt^tm1.1Lhy
Targeted Allele Detail

Summary

• Symbol: Ddt^tm1.1Lhy
• Name: D-dopachrome tautomerase; targeted mutation 1.1, Lawrence H Young
• MGI ID: MGI:7328697
• Synonyms: MIF-2^-
• Gene: Ddt Location: Chr10:75607067-75609208 bp, - strand Genetic Position: Chr10, 38.58 cM
• Alliance: Ddt^tm1.1Lhy page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:280996
• Parent Cell Line: v6.5 (ES Cell)
• Strain of Origin: (C57BL/6 x 129S4/SvJae)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 1 and an FRT flanked puro cassette and loxP site were inserted downstream of exon 2 via homologous recombination. Cre-mediated recombination in the germline resulted in the deletion of exons 1 and 2 and the puromycin selection cassette. (J:213776)

Tumor Data

List all tumor models in MMHCdb carrying Ddt^tm1.1Lhy

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ddt Mutation: 16 strains or lines available

References

• Original: J:280996 Ochi A, et al., MIF-2/D-DT enhances proximal tubular cell regeneration through SLPI- and ATF4-dependent mechanisms. Am J Physiol Renal Physiol. 2017 Sep 1;313(3):F767-F780
• All: 6 reference(s)