Ddx41^tm1Dsta
Targeted Allele Detail

Summary

• Symbol: Ddx41^tm1Dsta
• Name: DEAD box helicase 41; targeted mutation 1, Daniel T Starczynowski
• MGI ID: MGI:7328617
• Synonyms: Ddx41^{conditionalR525H}
• Gene: Ddx41 Location: Chr13:55678223-55684471 bp, - strand Genetic Position: Chr13, 30.06 cM
• Alliance: Ddx41^tm1Dsta page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:326963
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: A floxed cDNA cassette coding for exons 12-17 and STOP was inserted into intron 11 and an arginine to histidine substitution (p.R525H) was introduced in exon 15. Cre-mediated recombination can be used to remove the wild-type exons and result in expression of the mutant. (J:326963)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ddx41 Mutation: 46 strains or lines available

References

• Original: J:326963 Chlon TM, et al., Germline DDX41 mutations cause ineffective hematopoiesis and myelodysplasia. Cell Stem Cell. 2021 Nov 4;28(11):1966-1981.e6
• All: 1 reference(s)