Mdm2^tm1.1Khv
Targeted Allele Detail

Summary

• Symbol: Mdm2^tm1.1Khv
• Name: MDM2 proto-oncogene; targeted mutation 1.1, Karen H Vousden
• MGI ID: MGI:7328424
• Gene: Mdm2 Location: Chr10:117524780-117546663 bp, - strand Genetic Position: Chr10, 66.32 cM, cytoband C1-C3
• Alliance: Mdm2^tm1.1Khv page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:308554
• Parent Cell Line: HM-1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd-Hprt1^b-m3

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: A loxP site, wild-type exons 11/12, FRT-flanked neomycin selection cassette, a second loxP site, and exons 11/12 containing the isoleucine to lysine substitution at amino acid 438 (p.I438K) in exon 12 replaced exons 11 and 12. The neomycin cassette was removed via flp-mediated recombination. (J:308554)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mdm2 Mutation: 51 strains or lines available

References

• Original: J:308554 Humpton TJ, et al., Differential requirements for MDM2 E3 activity during embryogenesis and in adult mice. Genes Dev. 2021 Jan 1;35(1-2):117-132
• All: 1 reference(s)