Terb1^em1Hirok
Endonuclease-mediated Allele Detail

Summary

• Symbol: Terb1^em1Hirok
• Name: telomere repeat binding bouquet formation protein 1; endonuclease-mediated mutation 1, Hiroki Shibuya
• MGI ID: MGI:7327606
• Synonyms: Terb1^deltaMYB
• Gene: Terb1 Location: Chr8:105173351-105236542 bp, - strand Genetic Position: Chr8, 53.04 cM
• Alliance: Terb1^em1Hirok page

Mutation origin

• Strain of Origin: Not Applicable

Mutation description

• Allele Type: Endonuclease-mediated (Not Applicable)
• Mutation: Single point mutation
• Mutation details: CRISPR-targeting introduced the mutation responsible for the introduction of a stop codon instead of glycine at position 704 (G704*) resulting in a premature termination before the MYB-like DNA-binding (MYB) domain. (J:324793)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Terb1 Mutation: 47 strains or lines available

References

• Original: J:324793 Zhang K, et al., The TERB1 MYB domain suppresses telomere erosion in meiotic prophase I. Cell Rep. 2022 Jan 25;38(4):110289
• All: 1 reference(s)