Atg16l1^tm1.1Zhap
Targeted Allele Detail

Summary

• Symbol: Atg16l1^tm1.1Zhap
• Name: autophagy related 16 like 1; targeted mutation 1.1, Fuping Zhang
• MGI ID: MGI:7327518
• Gene: Atg16l1 Location: Chr1:87683730-87720150 bp, + strand Genetic Position: Chr1, 44.44 cM
• Alliance: Atg16l1^tm1.1Zhap page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:247658
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A floxed exon 9 containing a T300A mutation replaced exon 9 and an FRT flanked inverse orientation neo cassette was inserted in intron 9 via homologous recombination. Cre mediated recombination removed exon 9. (J:247658)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Atg16l1 Mutation: 46 strains or lines available

References

• Original: J:247658 Gao P, et al., The Inflammatory Bowel Disease-Associated Autophagy Gene Atg16L1T300A Acts as a Dominant Negative Variant in Mice. J Immunol. 2017 Mar 15;198(6):2457-2467
• All: 1 reference(s)