Il23r^{tm2c(EUCOMM)Wtsi}
Targeted Allele Detail

Summary

• Symbol: Il23r^{tm2c(EUCOMM)Wtsi}
• Name: interleukin 23 receptor; targeted mutation 2c, Wellcome Trust Sanger Institute
• MGI ID: MGI:7327509
• Synonyms: Il23r^fl
• Gene: Il23r Location: Chr6:67399916-67468839 bp, - strand Genetic Position: Chr6, 30.85 cM
• Alliance: Il23r^{tm2c(EUCOMM)Wtsi} page

Mutation origin

• Mutant Cell Line: EPD0812_2_C11
• Germline Transmission: Earliest citation of germline transmission: J:326995
• Parent Cell Line: JM8A3.N1 (ES Cell)
• Strain of Origin: C57BL/6N-A^tm1Brd

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion Vector: L1L2_Bact_P
• Mutation details: The L1L2_Bact_P cassette was inserted at position 67455672 of Chromosome 6 upstream of the critical exon(s) (Build GRCm39). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by a neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site is inserted downstream of the targeted exon(s) at position 67456563. The critical exon(s) is/are thus flanked by loxP sites. A conditional ready (floxed) allele was created by flp recombinase expression which removed the lacZ and neomycin selection cassette. (J:326995)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Il23r Mutation: 69 strains or lines available

References

• Original: J:326995 Schnell A, et al., Stem-like intestinal Th17 cells give rise to pathogenic effector T cells during autoimmunity. Cell. 2021 Dec 22;184(26):6281-6298.e23
• All: 1 reference(s)