Gt(ROSA)26Sor^{tm2(CAG-FGFR1*)Lyyu}
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{tm2(CAG-FGFR1*)Lyyu}
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 2, Luyang Yu
• MGI ID: MGI:7327489
• Synonyms: FGFR1-2KR^flox
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{tm2(CAG-FGFR1*)Lyyu} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:326750
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, Epitope tag, Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: The targeting construct introduced into the locus a CAG promoter, floxed stop codon, and FLAG-tagged human FGFR1 coding sequence with mutations responsible for two amino acid substitutions of lysine with arginine. (J:326750)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 1095 strains or lines available

References

• Original: J:326750 Zhu X, et al., FGFR1 SUMOylation coordinates endothelial angiogenic signaling in angiogenesis. Proc Natl Acad Sci U S A. 2022 Jun 28;119(26):e2202631119
• All: 1 reference(s)