Kirrel3^em1Jfcl
Endonuclease-mediated Allele Detail

Summary

• Symbol: Kirrel3^em1Jfcl
• Name: kirre like nephrin family adhesion molecule 3; endonuclease-mediated mutation 1, Jean-Francois Cloutier
• MGI ID: MGI:7327432
• Synonyms: Kirrel3^Q128A
• Gene: Kirrel3 Location: Chr9:34397190-34948012 bp, + strand Genetic Position: Chr9, 18.97 cM
• Alliance: Kirrel3^em1Jfcl page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Endonuclease-mediated (Not Applicable)
• Mutation: Nucleotide substitutions
• Mutation details: CRISPR/Cas9 technology generated a CAG to GCC codon change in exon 4 resulting in a glutamine to alanine substitution at amino acid 128 (p.Q128A). This mutation abolishes Kirrel3 dimerization. (J:326967)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Kirrel3 Mutation: 37 strains or lines available

References

• Original: J:326967 Wang J, et al., Molecular and structural basis of olfactory sensory neuron axon coalescence by Kirrel receptors. Cell Rep. 2021 Nov 2;37(5):109940
• All: 1 reference(s)