Mrps5^tm1.1Dshc
Targeted Allele Detail

Summary

• Symbol: Mrps5^tm1.1Dshc
• Name: mitochondrial ribosomal protein S5; targeted mutation 1.1, Dimitri Shcherbakov
• MGI ID: MGI:7327184
• Synonyms: MRPS5^FLEx
• Gene: Mrps5 Location: Chr2:127429346-127445906 bp, + strand Genetic Position: Chr2, 62.05 cM, cytoband F3
• Alliance: Mrps5^tm1.1Dshc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:325948
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: This allele was created using the FLEx switch system. A loxP site was inserted upstream of exon 10, a lox511 site, inverted exon 10 containing a glycine to arginine substitution at amino acid 315 (G315R), an FRT flanked neomycin selection cassette, loxP site in reverse orientation, and a lox511 site in reverse orientation were inserted downstream of exon 10. The neomycin cassette was removed via flp-mediated recombination. (J:325948)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mrps5 Mutation: 43 strains or lines available

References

• Original: J:325948 Juskeviciene R, et al., Phenotype of Mrps5-Associated Phylogenetic Polymorphisms Is Intimately Linked to Mitoribosomal Misreading. Int J Mol Sci. 2022 Apr 15;23(8)
• All: 1 reference(s)