Ccl2^tm1.1Jspa
Targeted Allele Detail

Summary

• Symbol: Ccl2^tm1.1Jspa
• Name: C-C motif chemokine ligand 2; targeted mutation 1.1, Joel S Pachter
• MGI ID: MGI:7316776
• Synonyms: CCL2^loxP
• Gene: Ccl2 Location: Chr11:81926403-81928278 bp, + strand Genetic Position: Chr11, 49.82 cM, cytoband C-E1
• Alliance: Ccl2^tm1.1Jspa page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:326708
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: (129 x C57BL/6J)F1

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted 2430 bp upstream of exon 1 and an FRT-flanked neomycin selection cassette and second loxP site were inserted 190 bp downstream of exon 3, resulting in a floxed 4501 bp fragment containing the complete gene. The selection cassette was removed via flp-mediated recombination, leaving exons 1-3 floxed. (J:326708)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ccl2 Mutation: 23 strains or lines available

References

• Original: J:326708 Ge S, et al., Astrocyte- and endothelial-targeted CCL2 conditional knockout mice: critical tools for studying the pathogenesis of neuroinflammation. J Mol Neurosci. 2009 Sep;39(1-2):269-83
• All: 2 reference(s)