Hcn2^tm1Chet
Targeted Allele Detail

Summary

• Symbol: Hcn2^tm1Chet
• Name: hyperpolarization-activated, cyclic nucleotide-gated K+ 2; targeted mutation 1, Dane Chetkovich
• MGI ID: MGI:7316479
• Synonyms: Hcn2^R, HCN2(R591E)
• Gene: Hcn2 Location: Chr10:79552468-79571942 bp, + strand Genetic Position: Chr10, 39.72 cM, cytoband C1
• Alliance: Hcn2^tm1Chet page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:325470
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Not Specified)
• Mutation: Nucleotide substitutions
• Mutation details: The targeting construct introduced the mutation responsible for the amino acid substitution arginine with glutamic acid at position 591 (R591E). (J:325470)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hcn2 Mutation: 29 strains or lines available

References

• Original: J:325470 Lyman KA, et al., Hippocampal cAMP regulates HCN channel function on two time scales with differential effects on animal behavior. Sci Transl Med. 2021 Nov 24;13(621):eabl4580
• All: 1 reference(s)