Gt(ROSA)26Sor^{em1(CAG-Wwc)Fxyu}
Endonuclease-mediated Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{em1(CAG-Wwc)Fxyu}
• Name: gene trap ROSA 26, Philippe Soriano; endonuclease-mediated mutation 1, Fa-Xing Yu
• MGI ID: MGI:7314961
• Synonyms: R26-e(CAG-LSL-3XFlag-SuperHippo)
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{em1(CAG-Wwc)Fxyu} page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Conditional ready, Epitope tag, Inserted expressed sequence, No functional change)
• Mutation: Insertion
• Mutation details: CRISPR-targeting inserted a CAG promoter, floxed stop cassette, a consensus sequence based on the first 200 amino acids of human WW, C2 and coiled-coil domain containing proteins with a triple FLAG-tag, WPRE sequence, and polyadenylation sequence. (J:325475)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 1095 strains or lines available

References

• Original: J:325475 Qi S, et al., WWC proteins mediate LATS1/2 activation by Hippo kinases and imply a tumor suppression strategy. Mol Cell. 2022 May 19;82(10):1850-1864.e7
• All: 1 reference(s)