Cd79b^{tm1.1(CD79B)Camb}
Targeted Allele Detail

Summary

• Symbol: Cd79b^{tm1.1(CD79B)Camb}
• Name: CD79B antigen; targeted mutation 1, John C Cambier
• MGI ID: MGI:7314919
• Synonyms: cCD79B
• Gene: Cd79b Location: Chr11:106202167-106205388 bp, - strand Genetic Position: Chr11, 68.89 cM
• Alliance: Cd79b^{tm1.1(CD79B)Camb} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:325486
• Parent Cell Line: JM8A3 (ES Cell)
• Strain of Origin: C57BL/6N-A^tm1Brd

Mutation description

• Allele Type: Targeted (Inserted expressed sequence, Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Cd79b^{tm1.1(CD79B)Camb} expresses 1 gene
  Knock-in expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  CD79B (974)

  Cd79b

  (MGI:96431)

• Mutation details: The targeting construct replaced the sequence coding for amino acids 29 to 153 of the endogenous sequence with the sequence encoding amino acids 29 to 154 of the human gene. Cre-mediated recombination removed the floxed selection cassette. (J:325486)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cd79b Mutation: 36 strains or lines available

References

• Original: J:325486 Wemlinger SM, et al., Preclinical Analysis of Candidate Anti-Human CD79 Therapeutic Antibodies Using a Humanized CD79 Mouse Model. J Immunol. 2022 Apr 1;208(7):1566-1584
• All: 1 reference(s)