Rr376^em1Jfz
Endonuclease-mediated Allele Detail

Summary

• Symbol: Rr376^em1Jfz
• Name: regulatory region 376; endonuclease-mediated mutation 1, Jinfang Zhu
• MGI ID: MGI:7314855
• Synonyms: Tbx21^5M
• Gene: Rr376 Location: Chr11:97017874-97018017 bp Genetic Position: Chr11, Syntenic
• Alliance: Rr376^em1Jfz page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Endonuclease-mediated (Not Applicable)
• Mutation: Nucleotide substitutions
• Mutation details: CRISPR-targeting mutated two conserved STAT binding motifs in the CNS-12 conserved sequence ~12 kb upstream of the Tbx21 transcriptional start site and introduced an FspI endonuclease restriction site (TGCGCA). (J:325490)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rr376 Mutation: 0 strains or lines available

References

• Original: J:325490 Fang D, et al., Differential regulation of transcription factor T-bet induction during NK cell development and T helper-1 cell differentiation. Immunity. 2022 Apr 12;55(4):639-655.e7
• All: 1 reference(s)