Tmem106b^em2Fehu
Endonuclease-mediated Allele Detail

Summary

• Symbol: Tmem106b^em2Fehu
• Name: transmembrane protein 106B; endonuclease-mediated mutation 2, Fenghua Hu
• MGI ID: MGI:7314854
• Synonyms: delta7bp, delta7bp Tmem106b^-
• Gene: Tmem106b Location: Chr6:13069758-13089268 bp, + strand Genetic Position: Chr6, 5.38 cM, cytoband A2
• Alliance: Tmem106b^em2Fehu page

Mutation origin

• Strain of Origin: C57BL/6J x FVB/N

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/Cas9 technology generated a 7 bp deletion after amino acid 39, resulting in a frame shift and early termination. (J:322137)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tmem106b Mutation: 29 strains or lines available

References

• Original: J:322137 Feng T, et al., A role of the frontotemporal lobar degeneration risk factor TMEM106B in myelination. Brain. 2020 Jul 1;143(7):2255-2271
• All: 2 reference(s)