Tinf2^em1Sggz
Endonuclease-mediated Allele Detail

Summary

• Symbol: Tinf2^em1Sggz
• Name: Terf1 (TRF1)-interacting nuclear factor 2; endonuclease-mediated mutation 1, Zhou Songyang
• MGI ID: MGI:7314748
• Synonyms: Tin2^S341X
• Gene: Tinf2 Location: Chr14:55912146-55919277 bp, - strand Genetic Position: Chr14, 28.19 cM
• Alliance: Tinf2^em1Sggz page

Mutation origin

• Strain of Origin: C57BL/6NJ

Mutation description

• Allele Type: Endonuclease-mediated (Not Specified)
• Mutation: Nucleotide substitutions
• Mutation details: CRISPR-targeting introduced the mutation responsible for the amino acid substitution of serine with a stop codon at position 341 (S341*). (J:325498)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tinf2 Mutation: 12 strains or lines available

References

• Original: J:325498 Yin S, et al., TIN2 deficiency leads to ALT-associated phenotypes and differentiation defects in embryonic stem cells. Stem Cell Reports. 2022 May 10;17(5):1183-1197
• All: 1 reference(s)