Tph2^{em1(HBEGF)Zfa}
Endonuclease-mediated Allele Detail

Summary

• Symbol: Tph2^{em1(HBEGF)Zfa}
• Name: tryptophan hydroxylase 2; endonuclease-mediated mutation 1, Zusen Fan
• MGI ID: MGI:7314681
• Synonyms: Tph2^DTR
• Gene: Tph2 Location: Chr10:114914546-115020927 bp, - strand Genetic Position: Chr10, 63.51 cM
• Alliance: Tph2^{em1(HBEGF)Zfa} page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Endonuclease-mediated (Inserted expressed sequence)
• Mutation: Insertion
• Tph2^{em1(HBEGF)Zfa} expresses 1 gene
  Knock-in expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  HBEGF (1839)

  Hbegf

  (MGI:96070)

• CRISPR-targeting of exon 11 inserted an HBEGF gene. (J:325980)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tph2 Mutation: 43 strains or lines available

References

• Original: J:325980 Zhu P, et al., 5-hydroxytryptamine produced by enteric serotonergic neurons initiates colorectal cancer stem cell self-renewal and tumorigenesis. Neuron. 2022 May 7
• All: 1 reference(s)