Xiaptm1c(EUCOMM)Hmgu
Targeted Allele Detail
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Symbol: |
Xiaptm1c(EUCOMM)Hmgu |
Name: |
X-linked inhibitor of apoptosis; targeted mutation 1c, Helmholtz Zentrum Muenchen GmbH |
MGI ID: |
MGI:7314428 |
Gene: |
Xiap Location: ChrX:41148556-41198533 bp, + strand Genetic Position: ChrX, 23.19 cM, cytoband A3-A5
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Alliance: |
Xiaptm1c(EUCOMM)Hmgu page
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IMPC: |
Xiap gene page |
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Germline Transmission: |
Earliest citation of germline transmission:
J:214844
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Parent Cell Line: |
JM8.N4 (ES Cell)
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Strain of Origin: |
C57BL/6N
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Project Collection: |
EUCOMM
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Allele Type: |
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Targeted (Conditional ready, No functional change) |
Mutation: |
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Insertion
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Mutation details: The L1L2_Bact_P cassette was inserted at position 41187242 of Chromosome X upstream of the critical exon(s) (Build GRCm39). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by a neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site is inserted downstream of the targeted exon(s) at position 41187998. The critical exon(s) is/are thus flanked by loxP sites. A "conditional ready" (floxed) allele was created by flp recombinase expression in mice carrying this allele. Subsequent cre expression results in a knockout mouse. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml
(J:214844)
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Xiap Mutation: |
37 strains or lines available
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Original: |
J:214844 Andree M, et al., BID-dependent release of mitochondrial SMAC dampens XIAP-mediated immunity against Shigella. EMBO J. 2014 Oct 1;33(19):2171-87 |
All: |
1 reference(s) |
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