Dync1li1^tm1.2Wtao
Targeted Allele Detail

Summary

• Symbol: Dync1li1^tm1.2Wtao
• Name: dynein cytoplasmic 1 light intermediate chain 1; targeted mutation 1.2, Wufan Tao
• MGI ID: MGI:7314410
• Gene: Dync1li1 Location: Chr9:114517899-114552856 bp, + strand Genetic Position: Chr9, 64.96 cM
• Alliance: Dync1li1^tm1.2Wtao page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:326301
• Parent Cell Line: W4 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The targeting construct introduced upstream of exon 5 an FRT site, lacZ reporter gene, FRT site, neomycin resistance cassette, FRT site, and loxP site. A second loxP site was inserted downstream of exon 5. Cre-mediated recombination removed exon 5 and left the reporter/selection cassette intact. Flp-mediated recombination removed the reporter/selection cassette. (J:326301)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dync1li1 Mutation: 57 strains or lines available

References

• Original: J:326301 Kong S, et al., Dlic1 deficiency impairs ciliogenesis of photoreceptors by destabilizing dynein. Cell Res. 2013 Jun;23(6):835-50
• All: 2 reference(s)