Fermt3^tm2Ref
Targeted Allele Detail

Summary

• Symbol: Fermt3^tm2Ref
• Name: fermitin family member 3; targeted mutation 2, Reinhard Fassler
• MGI ID: MGI:7312162
• Synonyms: K3ⁿ, kindlin-3 n
• Gene: Fermt3 Location: Chr19:6976326-6996837 bp, - strand Genetic Position: Chr19, 5.13 cM
• Alliance: Fermt3^tm2Ref page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:203436
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, Hypomorph)
• Mutation: Insertion
• Mutation details: Exons 3 to 6 were flanked by loxP sites. An FRT-flanked neomycin selection cassette was inserted in intron 6 before the second loxP site. The presence of the neo-cassette resulted in strongly reduced expression giving rise to a hypomorphic allele. (J:203436)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fermt3 Mutation: 30 strains or lines available

References

• Original: J:203436 Cohen SJ, et al., The integrin coactivator Kindlin-3 is not required for lymphocyte diapedesis. Blood. 2013 Oct 10;122(15):2609-17
• All: 4 reference(s)