Itgb2^tm1Grabs
Targeted Allele Detail

Summary

• Symbol: Itgb2^tm1Grabs
• Name: integrin beta 2; targeted mutation 1, Stephan Grabbe
• MGI ID: MGI:7312151
• Synonyms: CD18^fl, Itgb2^tm2.GrabS
• Gene: Itgb2 Location: Chr10:77366164-77401542 bp, + strand Genetic Position: Chr10, 39.72 cM
• Alliance: Itgb2^tm1Grabs page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:339851
• Parent Cell Line: JM8 (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 3, and an FRT-flanked neomycin cassette and second loxP site were inserted downstream of exon 3. The neomycin cassette was removed via flp-mediated recombination, leaving exon 3 floxed. (J:339851)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Itgb2 Mutation: 52 strains or lines available

References

• Original: J:339851 Klaus T, et al., Impaired Treg-DC interactions contribute to autoimmunity in leukocyte adhesion deficiency type 1. JCI Insight. 2022 Dec 22;7(24)
• All: 3 reference(s)