Cd5^tm1.1Nsnh
Targeted Allele Detail

Summary

• Symbol: Cd5^tm1.1Nsnh
• Name: CD5 antigen; targeted mutation 1.1, Nevil J Singh
• MGI ID: MGI:7312147
• Gene: Cd5 Location: Chr19:10695471-10716390 bp, - strand Genetic Position: Chr19, 7.16 cM
• Alliance: Cd5^tm1.1Nsnh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:294360
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: The targeting construct inserted upstream of exon 3 an FRT site, lacZ reporter gene, loxP site, neo cassette, FRT site, and loxP site. Another loxP site was inserted downstream of exon 3. Flp-mediated recombination removed the reporter/selection cassette. (J:294360)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cd5 Mutation: 34 strains or lines available

References

• Original: J:294360 Matson CA, et al., CD5 dynamically calibrates basal NF-kappaB signaling in T cells during thymic development and peripheral activation. Proc Natl Acad Sci U S A. 2020 Jun 23;117(25):14342-14353
• All: 2 reference(s)