Stx1b^tm1.2Rmnd
Targeted Allele Detail

Summary

• Symbol: Stx1b^tm1.2Rmnd
• Name: syntaxin 1B; targeted mutation 1.2, Christian Rosenmund
• MGI ID: MGI:7312053
• Gene: Stx1b Location: Chr7:127403072-127423703 bp, - strand Genetic Position: Chr7, 69.75 cM
• Alliance: Stx1b^tm1.2Rmnd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:238616
• Parent Cell Line: AB2.2 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 2. An FRT-flanked neomycin resistance cassette with a 3' loxP site was inserted downstream of exon 4. FLP1-mediated recombination in the germline resulted in the removal of the neomycin cassette and leaving loxP sites flanking exon 2-4. (J:238616)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Stx1b Mutation: 19 strains or lines available

References

• Original: J:238616 Wu YJ, et al., Syntaxin 1B is important for mouse postnatal survival and proper synaptic function at the mouse neuromuscular junctions. J Neurophysiol. 2015 Oct;114(4):2404-17
• All: 4 reference(s)