Pink1^tm1.2Ics
Targeted Allele Detail

Summary

• Symbol: Pink1^tm1.2Ics
• Name: PTEN induced putative kinase 1; targeted mutation 1.2, Mouse Clinical Institute
• MGI ID: MGI:7312014
• Gene: Pink1 Location: Chr4:138040720-138053618 bp, - strand Genetic Position: Chr4, 70.14 cM
• Alliance: Pink1^tm1.2Ics page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:273082
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 6 and 7 were flanked by loxP sites and an frt-flanked neomycin selection cassette was inserted and removed via flp-mediated recombination. Exons 6 and 7 were deleted via cre-mediated recombination. (J:273082)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pink1 Mutation: 43 strains or lines available

References

• Original: J:273082 Mouton-Liger F, et al., Parkin deficiency modulates NLRP3 inflammasome activation by attenuating an A20-dependent negative feedback loop. Glia. 2018 Aug;66(8):1736-1751
• All: 1 reference(s)