Akt3^tm1.1Guiq
Targeted Allele Detail

Summary

• Symbol: Akt3^tm1.1Guiq
• Name: Akt serine/threonine kinase 3; targeted mutation 1.1, Guiquan Chen
• MGI ID: MGI:7312001
• Synonyms: Akt3^f
• Gene: Akt3 Location: Chr1:176847639-177085769 bp, - strand Genetic Position: Chr1, 82.66 cM, cytoband H4-H6
• Alliance: Akt3^tm1.1Guiq page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:326435
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted into intron 2 and an FRT site flanked neomycin resistance gene cassette and a second loxP site into intron 3. The neo cassette was removed through subsequent flp-mediated recombination, leaving a conditional-ready allele with exon 3 floxed. (J:326435)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Akt3 Mutation: 40 strains or lines available

References

• Original: J:326435 Wang H, et al., Akt Regulates Sox10 Expression to Control Oligodendrocyte Differentiation via Phosphorylating FoxO1. J Neurosci. 2021 Sep 29;41(39):8163-8180
• All: 1 reference(s)